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Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
Sculpting nano-electrodes having a transmission electron beam for electrical and geometrical characterization of nanoparticles.
This yielded a breakthrough. Inside just a few months, we had been ready to measure transportation by way of an individual solitary-walled carbon nanotube. Based on lower-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Technology using an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes have been legitimate quantum wires with really extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
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Resolving the stage dimension in condensin-driven DNA loop extrusion identifies ATP binding as the step-building system
An integrated microfluidic platform for quantifying ceesdekker drug permeation across biomimetic vesicle membranes
Lots of new phenomena have been found, and he and his investigate group established a leading position With this area of investigate. Dekker and his analysis team identified new physics of nanotubes as well as explored the feasibility of molecular electronics. In 1998, they ended up the very first to develop a transistor determined by a single nanotube molecule.
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2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental review of ions conduction in nanofluidic channels; initial electrochemistry with unique solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; 1st electrical docking of microtubules on kinesin-coated nanostructures; initial biophysics characterization of your mechanical Homes of double-stranded RNA; and first solitary-molecule study of DNA translocation by a restriction-modification enzyme.