Making use of single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our exploration passions consist of:
Human Rad51 filaments on double- and solitary-stranded DNA: correlating typical and irregular varieties with recombination function.
Multicolor imaging with the bacterial nucleoid and mobile division proteins with blue, orange, and close to-infrared fluorescent proteins
Sculpting nano-electrodes with a transmission electron beam for electrical and geometrical characterization of nanoparticles.
De sterke polarisatie in de discussie rond schepping/evolutie en meer algemeen rond geloof/wetenschap lijkt helaas geen eind te kennen. Toch is er wel degelijk een heilzame middenweg, maar deze krijgt more than het algemeen weinig aandacht. Dit boek kan hier wellicht verandering in brengen. Wie de geschiedenis van de relatie tussen geloof en wetenschap in duikt, komt tot verrassende inzichten. De moderne mens leeft met veel stereotypen die historisch niet verantwoord blijken te zijn. Afgezaagde typeringen als ‘Vroeger dachten we dat de
Immediate immobilization of native yeast iso-one cytochrome c on bare gold: rapidly electron relay to redox enzymes and zeptomole protein-film voltammetry
Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with investigate from DNA supercoiling experiments of nucleosomes and DNA repair proteins to DNA translocation by means of nanopores. Just lately his investigate has centered on studying cell division with germs on chip, even though his best desire is in the route of noticing artificial cells.
Atomic pressure microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a very cooperative trend
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But carbon nanotubes have remained a investigation subject of significant curiosity to several. Certainly, the outlook on utilizing carbon nanotubes to build practical equipment, in spots which include radio-frequency electronics, electronic electronics and flexible electronics, remains vibrant.
‘The idea that There exists this kind of thing as being a starting, a giant bang, is already an interesting signpost to contemplate that there was a creator. But additional frequently, and on the basis of pure rationality, I also arrive at a Christian interpretation of reality. An atheistic worldview is actually a naturalistic worldview: basically, you can find only atoms and purely natural forces that we can measure.
2006, very first demonstration of molecular sorting inside of a lab on a chip making use of biomotors; discovery of nanobubbles in solid-state nanopores; and 1st estimate of electrokinetic Electrical power conversion inside a nanofluidic channel
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
Solid-state nanopores have confirmed to become a astonishingly flexible probe for single-molecule Evaluation of DNA. I will describe many of our recent findings – precisely DNA knots – as well as our endeavours to expand the abilities of stable-condition nanopores even even further, while in the route of solitary-protein ceesdekker.net detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.